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Research
Understanding the operation of multi-protein complexes and protein networks and how they endow any particular cell with its enormously precise and highly specific function are the central goals of our SFB. In this respect, many protein complexes act as nano-machineries whose activity and specificity is regulated via dynamic assembly of distinct partners and/or via post-translational modification(s). Research teams of the SFB 746 analyze the molecular mechanisms behind the specificity of protein complexes/protein networks and their significance for cellular functions. The research topics include the roles of protein complexes in signal transduction from the plasma membrane to the nucleus, for the control of gene transcription and for transport processes at and across membranes.
Research Projects
Prof. Dr. Roland Schüle (P2)
Assembly and signal-mediated regulation of the androgen receptor/LSD1 histone demethylation complex
Prof. Dr. Rudolf Grosschedl (P4)
Regulation of gene expression and nuclear architecture by MAR-binding proteins and SUMOylation
Prof. Dr. Ralf Baumeister (P5)
Protein modifications and interactions of the FOXO/DAF-16 mediated stress response
Prof. Dr. Michael Reth (P7)
Modifications and adaptor function of the B cell signalling proteins Syk and SHP-1
Prof. Dr. Sabine Rospert (P10)
Function of the Hsp70 homolog Ssb in the maintenance of cellular energy homeostasis
Signal sequence-dependent assembly of E. coli translocon subunits
Analysis of the protein nano-environments of the voltage-gated P/Q-type ca2+ channels Cav2.1 in the brain
Activation of G proteins by Pasteurella multocida toxin
The role of fomins as down-stream effector molecules of nephrocystins
Structure-function analysis of polar micro-domains in the Arabidopsis root
The molecular basis of the diversity and functional specificity of neuronal metabotropic glutamate receptor-mediated signaling
Modulation of sodium/proton exchanger activity by covalent modification and protein interaction
The protein sorting and assembly machinery of the mitochondrial outer membrane
Studying the molecular mechanisms underlying transcription regulation by the NSL complex
PD Dr. Sonja-Verena Albers (P24)
Effect of phosphorylation on the archaellum regulatory protein network
Prof. Dr. Nikolaus Pfanner (P25)
Role of membrane contact sites in preprotein translocation into mitochondria
Dr. Frank Edlich (P26)
Mitochondrial morphology regulatioh by dynamic Bcl-2 protein complexes
Dr. Thomas Boehm (P27)
Molecular basis of antigen recognition by variable lymphocyte receptors (VLRs)