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  • Download article...Hallacli E, Lipp M, Georgiev P, Spielman C, Cusack S, Akhtar A,* Kadlec J*. (2012) MSL1 mediated dimerization of the dosage compensation complex is essential for male X chromosome regulation in Drosophila. Molecular Cell 48, 587-600.* co-corresponding authors.

  • Download article... Conrad T, Cavalli FMG, Vaquerizas JM, Luscombe NM, Akhtar A. (2012) Dosage compensation in Drosophila is achieved by enhanced Pol II recruitment to male X-linked promoters. Science 337(6095):742-6. *co-corresponding authors.
    The above paper was highlighted in the following articles:
    MPG press release: Dosiskompensation bei Fliegenmaennchen.
    EMBL Press release: SF Neves (2012) Of flies and men.

  • Download article... Lam KC, Muelfordt F, Vaquerizas JM, Raja S, Luscombe NM, Manke T, Akhtar A. (2012) NSL complex regulates housekeeping genes in Drosophila. PLoS Genetics 8(6):e1002736. Epub 2012 Jun 14.

  • Download article... Conrad T,  Cavalli F, Hallacli E, Holz H, Kind J, Iilk I, Vaquerizas JM, Luscombe NM, Akhtar A. (2012) The MOF chromobarrel domain controls genomewide H4K16 acetylation and spreading of the MSL complex. Developmental Cell 22: 610-624.

  • Download article... Conrad T, Akhtar A. (2012) Dosage compensation in Drosophila: epigenetic fine-tuning of chromosome-wide transcription. Nature Reviews Genetics 13: 123-134.

  • Download article... Srinivasan, K., Leone, D.P., Bateson, R.K., Dobreva, G., Kohwi, Y., Kohwi-Shigematsu, T., Grosschedl, R., McConnell, S.K. (2012).  A network of genetic repression and derepression specifies projection fates in the developing neocortex.  Proc Natl Acad Sci U S A. 109, 19071-19078.

  • Download article...Nechanitzky, R., Dávila, A., Savarese, F., Fietze, S., Grosschedl, R. (2012).  Satb1 and Satb2 are dispensable for X chromosome inactivation in mice.  Dev Cell. 23, 866-871.

  • Download article... Wei, J., Shi, Y., Zheng, L., Zhou, B., Inose, H., Wang, J., Guo, X.E., Grosschedl, R., Karsenty, G. (2012).  miR-34s inhibit osteoblast proliferation and differentiation in the mouse by targeting SATB2.  J Cell Biol. 197, 509-521.

  • Download article...Böttinger L, Horvath SE, Kleinschroth T, Hunte C, Daum G, Pfanner N, Becker T (2012) Phosphatidylethanolamine and cardiolipin differentially affect the stability of mitochondrial respiratory chain supercomplexes. J. Mol. Biol. 423, 677-686

  • Download article...Gebert M, Schrempp SG, Mehnert CS, Heißwolf AK, Oeljeklaus S, Ieva R, Bohnert M, von der Malsburg K, Wiese S, Kleinschroth T, Hunte C, Meyer HE, Haferkamp I, Guiard B, Warscheid B, Pfanner N and Martin van der Laan M. (2012) Mgr2 promotes coupling of the mitochondrial presequence translocase to partner complexes. J. Cell Biol. 197, 595-604

  • Download article...Fröbel, J., Rose, P. & Müller, M. Twin-arginine-dependent translocation of folded proteins. Phil. Trans. R. Soc. B 367, 1029-1046 (2012)

  • Download article... Zoufaly, S., Fröbel, J., Rose, P., Flecken, T., Maurer, C., Moser, M. & Müller, M. Mapping precursor-binding site on TatC subunit of twin-arginine-specific protein translocase by site-specific photo cross-linking. J. Biol. Chem. 287, 13430-13441 (2012)

  • Download article... Lausberg, F., Fleckenstein, S., Kreutzenbeck, P., Fröbel, J., Rose, P., Müller, M. & Freudl. R. Genetic eveidence for a tight cooperation of TatB and TatC during productive recognition of twin-arginine (Tat) signal peptides in Escherichia coli. PLoS ONE 7, e39867 (2012)

  • Download article... Kneuper, H., Maldonado, B., Jäger, F., Krehenbrink, M., Buchanan, G., Keller, R., Müller, M., Berks, B.C. & Palmer, T. Molecular dissection of TatC defines critical regions essential for protein transport and a TatB-TatC contact site. Mol. Microbiol. 85, 945-961 (2012)

  • Download article...Fröbel, J., Rose, P., Lausberg, F., Blümmel, A.S., Freudl, R & Müller, M. Transmembrane insertion of twin-arginine signal peptides is driven by TatC and regulated by TatB. Nat. Commun. 3:1311 doi: 10.1038/ncomms2308 (2012).

  • Download article...Yang, J., and Reth, M. (2012). Drosophila S2 Schneider cells: a useful tool for rebuilding and redesigning approaches in synthetic biology. Methods Mol Biol 813:331-341.

  • Download article...Chiabudini M, Conz C, Reckmann F, Rospert S (2012) RAC/Ssb is required for translational repression induced by polylysine segments within nascent chains. Mol Cell Biol 32: 4769-4779

  • Download article...Zhang Y, Berndt U, Gölz H, Tais A, Oellerer S, Wölfle T, Fitzke E, Rospert S (2012) NAC functions as a modulator of SRP during the early steps of protein targeting to the ER. Mol Biol Cell 23: 3027-3040

  • Download article...Belyi Y, Tartakovskaya D, Tais A, Fitzke E, Tzivelekidis T, Jank T, Rospert S, Aktories K (2012) Elongation Factor 1A Is the Target of Growth Inhibition in Yeast Caused by Legionella pneumophila Glucosyltransferase Lgt1. J Biol Chem 287: 26029-26037

  • Download article...Schwenk J, Harmel N, Brechet A, Zolles G, Berkefeld H, Müller CS, Bildl W, Baehrens D, Hüber B, Kulik A, Klöcker N, Schulte U, Fakler B.

    High-resolution proteomics unravel architecture and full molecular diversity of native AMPA receptor complexes. Neuron 2012; 74(4):621-33.

  • Download article...Jeworutzki E, López-Hernández T, Capdevila-Nortes X, Sirisi S, Bengtsson L, Montolio M, Zifarelli G, Arnedo T, Müller CS, Schulte U, Nunes V, Martínez A, Jentsch TJ, Gasull X, Pusch M, Estévez R.

    GlialCAM, a Protein Defective in a Leukodystrophy, Serves as a ClC-2 Cl− Channel Auxiliary Subunit. Neuron 2012; 73(5):951-61.

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  • Download article...Bildl W, Haupt A, Müller CS, Biniossek ML, Thumfart JO, Hüber B, Fakler B, Schulte U.

    Extending the Dynamic Range of Label-free Mass Spectrometric Quantification of Affinity Purifications.

    Mol Cell Proteomics 2012; 11(2):M111.007955. Epub 2011 Nov 8.

  • Download article...Chaki M, Airik R, Ghosh A, Giles R, Chen R, Slaats G, Wang H, Hurd T, Zhou W, Cluckey A, Gee HY, Ramaswami G, Hong CH, Hamilton B, Cervenka I, Ganji RS, Bryja V, Arts H, van Reeuwijk J, Oud M, Letteboer S, Roepman r, Husson H, Ibraghimov-Beskrovnaya O, Yusunaga T, Walz G, Eley L, Sayer J, Schermer B, Liebau M, Benzing T, Le Corre S, Drummond I, Joles JA, Janssen S, Allen S, Natarajan S, O’Toole J, Attanasio M, Saunier S, Antignac C, Koenekoop R, Ren H, Lopez I, Nayir A, Stoetzel C, Dollfus H, Massoudi R, Gleeson J, Andreoli S, Doherty D, Lindstrad A, Golzio C, Katsanis N, Paper L, Abbound EB, Al-Rajih AA, Leiws RA, Lupski JR, Goldschmeding R, Omran H, Lee E, Wang S, Garner E, Anderson J, Shlomai J, Nurnberg G, Nurnberg P, Levy S, Smogorzewska A, Otto E, Hildebrand F. Exome capture reveals ZNF423 and CEP164 mutations, liniking renal ciliopathies to DNA damage response signaling. Cell 150: 533-48, 2012.

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    Lienkamp S, Liu K, Karner CM, Carroll TJ, Ronneberger O, Wallingford JB, Walz G. Kidney tubules elongate using a novel mode of planar cell polarity-dependent convergent extension. Nat Genet 44: 1382-1387, 2012.

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    Rao, S., Schmidt, O., Harbauer, A.B., Schönfisch, B., Guiard, B., Pfanner, N., and Meisinger, C. (2012). Biogenesis of the preprotein translocase of the outer mitochondrial membrane: protein kinase A phosphorylates the precursor of Tom40 and impairs its import. Mol. Biol. Cell 23, 1618-1627.

  • notavailable.png Wenz, L.S., Pfanner, N. and Becker, T. (2012) Mitochondriale Systeme für den Import von Proteinen. Biospektrum 18, 706-709.

  • Download article... Horvath, S.E., Böttinger, L., Vögtle, F.N., Wiedemann, N., Meisinger, C., Becker, T. and Daum, G. (2012) Processing and topology of the yeast mitochondrial phosphatidylserine decarboxylase 1. J. Biol. Chem. 287, 36744-36755.

  • Download article... Becker, T., Böttinger, L. and Pfanner, N. (2012) Mitochondrial protein import: from transport pathways to an integrated network. Trends Biochem. Sci., 37, 85-91.

  • Download article... Qi, W., Huang, X., Neumann-Haefelin, E., Schulze, E., and Baumeister, R. (2012) Cell-nonautonomous Signaling of FOXO/DAF-16 to the Stem Cells of C. elegans, PLoS Genetics, 8, e1002836.

  • Download article... Fatouros, C., Pir, G.P., Biernat, J., Koushika, S.P., Mandelkow, E., Mandelkow, E., Schmidt, E., Baumeister, R. (2012) Inhibition of Tau aggregation in a novel C. elegans model of Tauopathy mitigates proteotoxicity, Human Mol. Genet. 21, 3587-3603

  • Download article... Dalle Pezze P, Sonntag AG, Thien A, Prentzell MT, Gödel M, Fischer S, Neumann-Haefelin E, Huber TB, Baumeister R, Shanley DP, Thedieck K. (2012)  A dynamic network model of mTOR signaling reveals TSC-independent mTORC2 regulation. Science Signal. 2012 5, ra25

  • Download article... Liu, S., Schulze, E., and Baumeister, R. (2012). Temperature- and touch-sensitive neurons couple CNG and TRPV channel activities to control heat avoidance in Caenorhabditis elegans. PLoS One. 2012;7(3):e32360. 

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    Dühren-von Minden M, Übelhart R, Schneider D, Wossning T, Bach MP, Buchner M, Hofmann D, Surova E, Follo M, Köhler F, Wardemann H, Zirlik K, Veelken H, Jumaa H. Chronic lymphocytic leukaemia is driven by antigen-independent cell-autonomous signalling. Nature. 2012 Sep 13;489(7415):309-12

  • Download article... Alkhatib A, Werner M, Hug E, Herzog S, Eschbach C, Faraidun H, Köhler F, Wossning T, Jumaa H. FoxO1 induces Ikaros splicing to promote immunoglobulin gene recombination. J Exp Med. 2012 Feb 13;209(2):395-40

  • Download article...Zhu, Y., van Essen, D., and Saccani, S. (2012). Cell-Type-Specific Control of Enhancer Activity by H3K9 Trimethylation. Mol Cell 46, 408-423.

  • Download article... Saccani, S. (2012). All p65-containing dimers are not equal. Cell cycle 11, 646-647.

  • Download article... Y. Belyi, D. Tartakovskaya, A. Tais, E. Fitzke, T. Tzivelekidis, T. Jank, S. Rospert, K. Aktories, Elongation factor 1A is the target of growth inhibition in yeast caused by Legionella pneumophila glucosyltransferase Lgt1. J. Biol. Chem. (2012).

  • Download article... G. Guttenberg, S. Hornei, T. Jank, C. Schwan, W. Lu, O. Einsle, P. Papatheodorou, K. Aktories, Molecular characteristics of Clostridium perfringens TpeL toxin and consequences of mono-O-GlcNAcylation of Ras in living cells. J. Biol. Chem. 287, 24929 (2012).

  • Download article... T. Jank, K. E. Bohmer, T. Tzivelekidis, C. Schwan, Y. Belyi, K. Aktories, Domain organization of Legionella effector SetA. Cell Microbiol. 14, 852 (2012).

  • Download article... E. Kaiser, N. Bohm, K. Ernst, S. Langer, C. Schwan, K. Aktories, M. Popoff, G. Fischer, H. Barth, FK506-binding protein 51 interacts with Clostridium botulinum C2 toxin and FK506 inhibits membrane translocation of the toxin in mammalian cells. Cell Microbiol. (2012).

  • Download article... J. H. Orth, K. Aktories, Molecular Biology of Pasteurella multocida Toxin. Curr. Top. Microbiol. Immunol. 361, 73 (2012).

  • Download article... P. Papatheodorou, C. Wilczek, T. Nolke, G. Guttenberg, D. Hornuss, C. Schwan, K. Aktories, Identification of the cellular receptor of Clostridium spiroforme toxin. Infect. Immun. 80, 1418 (2012).

  • Download article... S. Reipschlaeger, K. Kubatzky, S. Taromi, M. Burger, J. Orth, K. Aktories, G. Schmidt, Toxin-induced RhoA activity mediates CCL1-triggered STAT signaling. J. Biol. Chem. (2012).

  • Download article... T. R. Stankiewicz, F. A. Loucks, E. K. Schroeder, M. T. Nevalainen, K. L. Tyler, K. Aktories, R. J. Bouchard, D. A. Linseman, Signal transducer and activator of transcription-5 mediates neuronal apoptosis induced by the inhibition of Rac GTPase activity. J. Biol. Chem. (2012).

  • notavailable.png Sprüssel, A., Schulte, J.H., Weber, S., Necke, M., Händschke, K., Thor, T., Pajtler, K.W., Schramm, A., König, K., Diehl, L., Mestdagh, P., Vandesompele, J., Speleman, F., Jastrow, H., Heukamp, L.C., Schüle, R., Dührsen, U., Buettner, R., Eggert, A. and Göthert, J.R. (2012) Lysine-specific demethylase 1 restricts hematopoietic progenitor proliferation and is essential for terminal
    differentiation. Leukemia 26, 2039-2051.

  • notavailable.png Ibrahim, S.A, Yip, G.W., Stock, C., Pan, J.W., Neubauer, C., Poeter, M., Pupjalis, D., Koo, C.Y., Kelsch, R, Schüle, R., Rescher, U., Kiesel, L. and Götte, M. (2012). Targeting of syndecan-1 by microRNA miR-10b promotes breast cancer cell motility and invasiveness via a Rho-GTPase- and Ecadherin-dependent mechanism. Int J Cancer 131, 884-896.Signal transducer and activator of transcription-5 mediates neuronal apoptosis induced by the inhibition of Rac GTPase activity. J. Biol. Chem. (2012).

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    Willmann, D., Lim, S., Wetzel, S., Metzger, E., Jandausch, A., Wilk, W., Jung, M., Forne, I., Imhof, A., Janzer, A., Kirfel, J., Waldmann, H., Schüle, R. and Buettner. R. (2012). Impairment of prostate
    cancer cell growth by a selective and reversible lysine-specific demethylase 1 inhibitor. Int J Cancer 131, 2704-2709.

  • notavailable.png Kaufmann, K.B., Gründer, A., Hadlich, T., Wehrle, J., Gothwal, M., Bogeska, R., Seeger, T.S., Kayser, S., Pham, K.-B., Jutzi, J.S., Ganzenmüller, L., Steinemann, D., Schlegelberger, B., Wagner, J.M., Jung, M., Will, B., Steidl, U., Aumann, K., Werner, M., Günther, T., Schüle, R., Rambaldi, A. and Pahl, H. (2012). Overexpression of transcription factor NF-E2: a novel murine model of myoloproliferative disorders. J. Ex Med. 209, 35-50.

  • Download article...Sprüssel A, Schulte JH, Weber S, Necke M, Händschke K, Thor T, Pajtler KW, Schramm A, König K, Diehl L, Mestdagh P, Vandesompele J, Speleman F, Jastrow H, Heukamp LC, Schüle R, Dührsen U, Buettner R, Eggert A and Göthert JR (2012) Lysine-specific demethylase 1 restricts hematopoietic
    progenitor proliferation and is essential for terminal differentiation. Leukemia 26, 2039-2051.

  • Download article...Willmann D, Lim S, Wetzel S, Metzger E, Jandausch A, Wilk W, Jung M, Forne I, Imhof A, Janzer A, Kirfel J, Waldmann H, Schüle R and Buettner R (2012). Impairment of prostate cancer cell growth by a selective and reversible lysine-specific demethylase 1 inhibitor. Int. J. Cancer 131, 2704-2709.

  • Download article...Skokowa J, Klimiankou M, Klimenkova O, Lan D, Gupta K, Hussein K, Carrizosa E, Kusnetsova I, Li Z, Sustmann C, Ganser A, Zeidler C, Kreipe HH, Burkhardt J, Grosschedl R, Welte K (2012) Interactions among HCLS1, HAX1 and LEF-1 proteins are essential for G-CSF-triggered granulopoiesis. Nat Med.
    18, 1550-1559.

  • Download article...Wei J, Shi Y, Zheng L, Zhou B, Inose H, Wang J, Guo XE, Grosschedl R, Karsenty G (2012) miR-34s inhibit osteoblast proliferation and differentiation in the mouse by targeting SATB2. J Cell Biol. 197, 509-521.

  • Download article...Schwenk J, Harmel N, Brechet A, Zolles G, Berkefeld H, Müller CS, Bildl W, Baehrens D, Huber B, Kulik A, Klöcker N, Schulte U* and Fakler B* (2012) High-resolution proteomics unravel architecture and
    molecular diversity of native AMPA receptor complexes. Neuron 74, 621-633 (*corresponding).Text Autor.

  • Download article...Seddik R, Jungblut SP, Silander OK, Rajalu M, Fritzius T, Besseyrias V, Jacquier V, Fakler B, Gassmann M and Bettler B (2012) Opposite effects of KCTD subunit domains on GABAB receptor-mediated
    desensitization. J Biol Chem 287, 39869-39877.Text Autor.

  • Download article...Guttenberg G, Hornei S, Jank T, Schwan C, Lu W, Einsle O, Papatheodorou P, Aktories K (2012) Molecular characteristics of Clostridium perfringens TpeL toxin and consequences of mono-OGlcNAcylation of Ras in living cells. J Biol Chem 287, 24929-24940.

  • Download article...Jank T, Bohmer KE, Tzivelekidis T, Schwan C, Belyi Y, Aktories K (2012) Domain organization of Legionella effector SetA. Cell Microbiol 14, 852-868.

  • Download article...Reipschlaeger S, Kubatzky K, Taromi S, Burger M, Orth J, Aktories K, Schmidt G (2012) Toxin-induced RhoA activity mediates CCL1-triggered signal transducers and activators of transcription protein signaling. J Biol Chem 287, 11183-11194

  • Download article...Dal Bosco C, Dovzhenko A, Liu X, Woerner N, Rensch T, Eismann M, Eimer S, Hegermann J, Paponov IA, Ruperti B, Heberle-Bors E, Touraev A, Cohen CD, Palme K (2012) The endoplasmic reticulum localized PIN8 is a pollen specific auxin carrier involved in intracellular auxin homeostasis. Plant J 71, 860-870

  • Download article...Singh MJ, Ren F, Giesemann T, Dal Bosco C, Ruperti B, Schmidt G, Aktories K, Molendijk AJ, Palme K (2012) Modification of plant Rac/Rop GTPase using bacterial toxin transgenes. Plant J 73, 314-324

  • Download article...Bohnert M, Wenz LS, Zerbes RM, Horvath SE, Stroud DA, von der Malsburg K, Müller JM, Oeljeklaus S, Perschil I, Warscheid B, Chacinska A, Veenhuis M, van der Klei IJ, Daum G, Wiedemann N, Becker T, Pfanner N* and van der Laan M* (2012) Role of mitochondrial inner membrane organizing system in protein biogenesis of the mitochondrial outer membrane. Mol. Biol. Cell 23, 3948-3956 (*corresponding).

  • Download article...van der Laan M, Bohnert M, Wiedemann N and Pfanner N (2012) Role of MINOS in mitochondrial membrane architecture and biogenesis. Trends Cell Biol. 22, 185-192 (overview on MINOS/MICOS).

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