You are here: Home Research
Document Actions


Central goal of SFB research

Understanding the operation of multi-protein complexes and protein networks and how they endow any particular cell with its enormously precise and highly specific function are the central goals of our SFB. In this respect, many protein complexes act as nano-machineries whose activity and specificity is regulated via dynamic assembly of distinct partners and/or via post-translational modification(s). Research teams of the SFB 746 analyze the molecular mechanisms behind the specificity of protein complexes/protein networks and their significance for cellular functions. The research topics include the roles of protein complexes in signal transduction from the plasma membrane to the nucleus, for the control of gene transcription and for transport processes at and across membranes.

Research Projects

Prof. Dr. Roland Schüle (P2)
Assembly and signal-mediated regulation of the androgen receptor/LSD1 histone demethylation complex 


Prof. Dr. Rudolf Grosschedl  (P4)
Regulation of gene expression and nuclear architecture by MAR-binding proteins and SUMOylation

Prof. Dr. Ralf Baumeister
Protein modifications and interactions of the FOXO/DAF-16 mediated stress response


Prof. Dr. Michael Reth (P7)

Modifications and adaptor function of the B cell signalling proteins Syk and SHP-1


Prof. Dr. Sabine Rospert (P10)
Function of the Hsp70 homolog Ssb in the maintenance of cellular energy homeostasis

Prof. Dr. Matthias Müller (P13)

Signal sequence-dependent assembly of E. coli translocon subunits 

Prof. Dr. Bernd Fakler (P16)

Analysis of the protein nano-environments of the voltage-gated P/Q-type ca2+ channels Cav2.1 in the brain 


Activation of G proteins by Pasteurella multocida toxin


The role of fomins as down-stream effector molecules of nephrocystins


Structure-function analysis of polar micro-domains in the Arabidopsis root


The molecular basis of the diversity and functional specificity of neuronal metabotropic glutamate receptor-mediated signaling


Modulation of sodium/proton exchanger activity by covalent modification and protein interaction


The protein sorting and assembly machinery of the mitochondrial outer membrane 


Studying the molecular mechanisms underlying transcription regulation by the NSL complex

PD Dr. Sonja-Verena Albers
Effect of phosphorylation on the archaellum regulatory protein network

Prof. Dr. Nikolaus Pfanner
Role of membrane contact sites in preprotein translocation into mitochondria

Dr. Frank Edlich (P26)
Mitochondrial morphology regulatioh by dynamic Bcl-2 protein complexes

Dr. Thomas Boehm (P27)
Molecular basis of antigen recognition by variable lymphocyte receptors (VLRs)

Personal tools