P 16 - Prof. Dr. Bernd Fakler
Analysis of the protein nano-environments of the voltage-gated P/Q-type Ca2+ channels Cav2.1 in the brain
| Prof. Dr. Bernd Fakler Institut für Physiologie II Hermann-Herder-Str. 7 79104 Freiburg Phone: +49 761 203-5175 Fax: +49 761 203-5191 |
Project Summary
Voltage-gated Ca2+ (Cav) channels are key elements linking excitability to a large variety of cellular processes via local Ca2+ signalling that occurs in defined spatial domains around the Cav channels, termed nano-environments. As the molecular basis behind nano-environments we have identified extended protein networks resulting from co-assembly of Cav channels with distinct partner proteins and subsequent cross-interactions between individual modules (network strings). Using proteomic techniques and functional recordings we have characterized some of these strings including those of Cav2 channels with GABAB receptors, Ca2+-activated ion channels and Ca2+-controlled enzymatic activities. |