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2014

 

    2014

  • Download article...LSD1 promotes oxidative metabolism of white adipose
    tissue.  Duteil D, Metzger E, Willmann D, Karagianni P, Friedrichs N, Greschik H, Günther T, Buettner R, Talianidis I, Metzger D and Schüle R. Nat Commun. 5, 4093

  • Download article...LSD1 regulates differentiation onset and migration of trophoblast stem cells. Zhu D, Hölz S, Metzger E, Pavlovic M, Jandausch A, Jilg C, Galgoczy P, Herz C, Moser M, Metzger D, Günther T, Arnold SJ and Schüle R. Nat Commun. 5, 3174

  • Download article...Phosphorylation of LSD1 by PKCα Is crucial for circadian rhythmicity and phase resetting. Nam HJ, Boo K, Kim DH, Choe HK, Kim CR, Sun W, Kim H, Kim K, Lee H, Metzger E, Schüle R, Yoo SH, Takahashi JS, Cho S, Son GH and Baek SH. Mol Cell 53, 791-805

  • Download article...CtBP and associated LSD1 are required for transcriptional activation by NeuroD1 in gastrointestinal endocrine cells. Ray SK, Li HJ, Metzger M, Schüle R and Leiter AB. Mol Cell Biol. 34, 2308-2317

  • Download article...Rosenbaum M, Andreani V, Kapoor T, Herp S, Flach H, Duchniewicz M, Grosschedl R (2014) MZB1 is a GRP94 cochaperone that enables proper immunoglobulin heavy chain biosynthesis upon ER stress. Genes Dev. 28, 1165-1178.

  • Download article...Wolf, T, Q, W, Schindler, V, Runkel, ED, and Baumeister, R (2014) Doxycyclin ameliorates a starvationinduced germline tumor in C. elegans daf-18/PTEN mutant background. Exp Gerontol 56, 114-122.

  • Download article...Runkel, ED, Baumeister, R, and Schulze, E (2014) Mitochondrial stress: Balancing friend and foe. Exp Gerontol 56, 194-201 (review).

  • Download article...Kläsener K, Maity PC, Hobeika E, Yang J, Reth M. (2014) B cell activation involve nanoscale receptor reorganizations and inside-out signaling by Syk. eLife 2014:3:e02069 doi:10.7554/eLife.02069

  • Download article...Alsadeq A, Hobeika E, Medgyesi D, Kläsener K, and Reth M. (2014) The role of the Syk/Shp-1 kinasephosphatase equilibrium in B cell development and signaling. J Immunol doi:10.4049/jimmunol.1203040

  • Download article...Medgyesi D, Hobeika E, Biesen R, Kollert F, Taddeo A, Voll R, Hiepe F and Reth M. (2014) The protein tyrosine phosphatase PTP1B is a negative regulator of CD40 and BAFF-R signaling and controls B cell autoimmunity. J Exp Med 211:427-440

  • Download article...Karamyshev AL, Patrick AE, Karamysheva ZN, Griesemer DS, Hudson H, Tjon-Kon-Sang S, Nilsson I, Otto H, Liu Q, Rospert S, Heijne G, Johnson AE, Thomas PJ (2014) Inefficient SRP Interaction with a Nascent Chain Triggers a mRNA Quality Control Pathway. Cell 156, 146-157.

  • Download article...Boudkkazi S, Brechet A, Schwenk J and Fakler B (2014) Cornichon2 dictates the time course of excitatory transmission at individual hippocampal synapses. Neuron 82, 848-858.

  • Download article...Turecek R, Schwenk J, Fritzius T, Ivankova K, Zolles G, Adelfinger L, Jacquier V, Besseyras V, Gassmann M, Schulte U, Fakler B* and Bettler B* (2014) Auxiliary GABAB receptor-subunits uncouple Gprotein βγ-subunits from effector channels to induce desensitization. Neuron 82, 1032-1044.

  • Download article...Meusch D, Gatsogiannis C, Efremov RG, Lang AE, Hofnagel O, Vetter IR, Aktories K, Raunser S (2014) Mechanism of Tc toxin action revealed in molecular detail. Nature 508, 61-65.

  • Download article...Ramachandran H, Schafer T, Kim Y, Herfurth K, Hoff S, Lienkamp SS, Kramer-Zucker A, and Walz G (2014) Interaction with the Bardet-Biedl gene product TRIM32/BBS11 modifies the half-life and
    localization of Glis2/NPHP7. J Biol Chem 289, 8390-401.

  • Download article...Schmidt T, Pasternak T, Liu K, Blein T, Aubry-Hivet D, Dovzhenko A, Dürr J, Teale W, Ditengou FA, Burkhardt H, Ronneberger O, Palme K (2014) The iRoCS Toolbox – 3D analysis of the plant root apical
    meristem at cellular resolution. Plant J 77, 806-814

  • Download article...Lentes CJ, Mir SM, Boehm M, Ganea C, Fendler K, Hunte C (2014) Molecular characterization of the Na+/H+ antiporter NhaA from Salmonella Typhimurium. PLoS One, doi:10.1371/journal.pone.0101575, accepted for publication (June 21, 2014).

  • Download article...Birth D, Kao WC, Hunte C (2014) Structural analysis of atovaquone-inhibited cytochrome bc1 complex reveals the molecular basis of antimalarial drug action. Nat. Commun. 5, 4029.

  • Download article...Calinescu O, Danner E, Böhm M, Hunte C and Fendler K (2014b) Species differences in bacterial NhaA Na+/H+ exchangers. FEBS Lett., accepted for publication (May 2, 2014).

  • Download article...Wenz, L.S., Opalinski, L., Schuler, M.H., Ellenrieder, L., Ieva, R., Böttinger, L., Qiu, J., van der Laan, M., Wiedemann, N., Guiard, B., Pfanner, N., and Becker, T. (2014). The presequence pathway is involved in protein sorting to the mitochondrial outer membrane. EMBO Rep. 15, 678-685.

  • Download article...Dias J, Nguyen NV, Georgiev P, Gaub A, Brettschneider J, Cusack S, Kadlec J and Akhtar A (2014) Structural analysis of the KANSL1/WDR5/KANSL2 complex reveals that WDR5 is required for efficient assembly and chromatin targeting of the NSL complex. Genes Dev. 28, 929-942.

  • Schmitt, M.L., Ladwein, K.I., Carlino, L., Schulz-Fincke, J., Willmann, D., Metzger, E., Schilcher, P., Imhof, A., Schüle, R., Sippl, W. and Jung, M. (2014) Heterogeneous antibody based activity assay for lysine specific demethylase 1 (LSD1) on a histone peptide substrate. J. Biomol. Screen 19, 973-978.

  • Pohlkamp, T., Steller, L., May, P., Guenther, T., Schüle, R., Frotscher, M., Herz, J. and Bock, H.H. (2014) Generation and Characterization of an Nse-CreERT2 Transgenic Line Suitable for Inducible Gene Manipulation in Cerebellar Granule Cells. PLoS One 9, e100384

  • Ketscher, A., Jilg, CA., Willmann, D., Hummel, B., Imhof, A., Rüsseler, V., Hölz, S., Müller, JM., Metzger, E. and Schüle, R. (2014) LSD1 controls metastasis of androgen-independent prostate cancer cells through PXN and LPAR6. Oncogenesis 3, e120.

  • Cai, C., He, H.H., Gao, S., Chen, S., Yu, Z., Gao, Y., Chen, S., Chen, M.W., Zhang, J., Ahmed. A., Wang, Y., Metzger, E., Schüle, R., X. Liu, X.S., Myles Brown, M. and Steven P. Balk, S.P. (2014) Lysine Specific Demethylase 1 has Dual Functions as a Major Regulator of Androgen Receptor Transcriptional Activity. Cell Rep. 9, 1618-1627.

  • Combs, S.E., Debus, J., Feick, G., Hadaschik, B., Hohenfellner, M., Schüle, R., Zacharias, J.P. and Schwardt, M. (2014) Current state of the art, multimodality research and future visions for the treatment of patients with prostate cancer: consensus results from Challenges and Chances in Prostate Cancer Research Meeting 2014. Radiat Oncol. 9, 224.

  • Kao WC, Hunte C (2014) The molecular evolution of the Qo motif. Genome Biol. Evol. 6, 1894-1910

  • Shahapure R, Driessen RP, Haurat MF, Albers SV, Dame RT (2014). The archaellum: a rotating type IV pilus. Mol Microbiol, 91:716-23

  • download.pngChiabudini M, Tais A, Zhang Y, Hayashi S, Wölfle T, Fitzke E, Rospert S (2014) Release factor eRF3 mediates premature translation termination on polylysine-stalled ribosomes in Saccharomyces cerevisiae. Mol Cell Biol 34: 4062-4076

  • download.pngBassett AR, Akhtar A, Barlow DP, Bird AP, Brockdorff N, Duboule D, Ephrussi A, Ferguson-Smith AC, Gingeras TR, Haerty W, Higgs DR, Miska EA, and Ponting CP (2014) Considerations when investigating lncRNA function in vivo. eLife;10.7554/eLife.03058

  • download.pngChelmicki T, Dündar F, Turley M, Khanam T, Aktas T, Ramírez F, Gendrel AV, Heard E, Manke T, Akhtar A (2014) MOF complexes use short and long-range interactions to ensure stem cell identity and Xist repression. eLife;10.7554/eLife.02024.



  • download.pngQuinn JJ, Ilik AI, Qu K, Georgiev P, Chu C, Akhtar A, Chang HY (2014) Domain ChIRP reveals the modularity of long noncoding RNA architecture, function, and target genes. Nature Biotechnology 32, 933–940.

  • notavailable.pngBaracho GV, Cato MH, Zu Z, Jaren OR, Hobeika E, Reth M, Rickert RC. (2014). PDK1 regulates B cell differentiation and homeostasis. Proc Natl Acad Sci USA 111(26):9573-9578.


  • notavailable.pngGrötsch B, Brachs S, Lang C, Luther J, Derer A, Schlötzer-Schrehardt U, Bozec A, Fillatreau S, Berberich I, Hobeika E, Reth M, Wagner EF, Schett G, Mielenz D, David JP. (2014). The AP-1 transcription factor Fra1 inhibits follicular B cell differentiation into plasma cells. J Exp Med 211(11):2199-212.

  • notavailable.pngHug E, Hobeika E, Reth M, Jumaa H. (2014). Inducible expression of hyperactive Syk in B cells activates Blimp-1-dependent terminal differentiation. Oncogene 33(28): 3730-3741.


  • notavailable.pngHutzler S, Özgör L, Naito-Matsui Y, Kläsener K, Winkler TH, Reth M, Nitschke L. (2014). The ligand-binding domain of Siglec-G is crucial for its selective inhibitory function on B1 cells. J Immunol 192(11):5406-5414.

  • notavailable.pngKlasen C, Ohl K, Sternkopf M, Shachar I, Schmitz C, Heussen N, Hobeika E, Levit-Zerdoun E, Tenbrock K, Reth M, Bernhagen J, El Bounkari O. (2014). MIF promotes B cell chemotaxis through the receptors CXCR4 and CD74 and ZAP-70 signaling. J Immunol 192(11):5273-5284.



  • notavailable.pngKönigsberger S, Weis V, Prodöhl J, Stehling M, Hobeika E, Reth M, Kiefer F. (2014). Suboptimal B-cell antigen receptor signaling activity in vivo elicits germinal center counterselection mechanisms. EUR J Immunol Nov 8. doi: 10.1002/eji.201444538.

  • notavailable.pngMaity PC, Yang J, Kläsener K, Reth M. (2014). The nanoscale organization of the B lymphocyte membrane. Biochem Biophys Acta Nov 15. pii: S0167-4889(14)00399-1. doi: 10.1016/j.bbamcr.2014.11.010.


  • notavailable.pngReth, M. Pillars article. antigen receptor tail clue. Nature. 1989.338:383-384. (2014). J Immunol 192(9):415-416.

  • notavailable.pngReth, M, Nielsen P. (2014). Signaling circuits in early B-cell development. Adv Immunol 122: 129-175.

  • notavailable.pngUmiker BR, McDonald G, Larbi A, Medina CO, Hobeika E, Reth M, Imanishi-Kari T. (2014). Production of IgG autoantibody requires expression of activation-induced deaminase in early-developing B cells in a mouse model of SLE. Eur J Immunol. Oct;44(10):3093-108. doi: 10.1002/eji.201344282.

  • notavailable.pngHarbauer, A.B., Opalinska, M., Gerbeth, C., Herman, J.S., Rao, S., Schönfisch, B., Guiard, B., Schmidt, O., Pfanner, N., and Meisinger, C. (2014). Cell cycle-dependent regulation of mitochondrial preprotein translocase. Science 346, 1109-1113.

  • notavailable.pngGold, V.A.M., Ieva, R., Walter, A., Pfanner, N., van der Laan, M., and Kühlbrandt, W. (2014). Visualizing active membrane protein complexes by electron cryo-tomography. Nat. Commun. 5, 4129.

  • notavailable.pngIeva, R, Schrempp, S.G., Opalinski, L., Wollweber, F., Höß, P., Heißwolf, A.K., Gebert, M., Zhang, Y., Guiard, B., Rospert, S., Becker, T., Chacinska, A., Pfanner, N., and van der Laan, M. (2014). Mgr2 functions as lateral gatekeeper for preprotein sorting in the mitochondrial inner membrane.Mol. Cell 56, 641-652.

  • notavailable.pngHarbauer, A.B., Zahedi, R.P., Sickmann, A., Pfanner, N., and Meisinger, C. (2014). The protein import machinery of mitochondria – a regulatory hub in metabolism, stress, and disease. Cell Metab. 19, 357-372.

  • notavailable.pngPfanner, N., van der Laan, M., Amati, P., Capaldi, R.A., Caudy, A.A., Chacinska, A., Darshi, M., Deckers, M., Hoppins, S., Icho, T., Jakobs, S., Ji, J., Kozjak-Pavlovic, V., Meisinger, C., Odgren, P.R., Park, S.K., Rehling, P., Reichert, A.S., Sheikh, M.S., Taylor, S.S., Tsuchida, N., van der Bliek, A.M., van der Klei, I.J., Weissman, J.S., Westermann, B., Zha, J., Neupert, W., and Nunnari, J. (2014). Uniform nomenclature for the mitochondrial contact site and cristae organizing system. J. Cell Biol. 204,1083-1086.

  • notavailable.pngOpalinski, L., Becker, T., and Pfanner, N. (2014). Clearing tail-anchored proteins from mitochondria. Proc. Natl. Acad. Sci. USA 111, 7888-7889.

    56, 641-652.

 
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