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    before 2010

  • Download article...Zhou Y, Schmitz K-M, Mayer C, Yuan X, Akhtar A, Grummt I. (2009) Reversible acetylation of the chromatin remodeling complex NoRC is required for noncoding RNA-dependent transcriptional silencing. Nature Cell Biology 11:1010-1016.

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    Kind J, Vaquerizas J, Gebhardt P, Gentzel M, Luscombe NM, Bertone   P, Akhtar A. (2008) Genomewide analysis revealed MOF as key regulator of gene dosage compensation and gene expression in Drosophila. Cell 133: 813-828.

    The above paper was highlighted in the following article:

    Preview: Ercan S, Lieb JD. (2008) Chromatin proteins do double duty. Cell 133:763-765.

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    Bell O, Conrad T, Kind J, Wirbelauer C, Akhtar A,* Schubeler D*. (2008) Transcription-coupled methylation of histone H3 at lysine 36 enhances recruitment of the MSL complex to the X chromosome in Drosophila. Molecular and Cellular Biology 28: 3401-3409.*co-corresponding authors

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    Pfister S, Rea S, Taipale M, Mendrzyk F, Straub B, Ittrich C, Thuerigen O, Sinn HP, Akhtar A*, Lichter P*. (2008) The histone acetyltransferase hMOF is frequently downregulated in primary breast carcinoma and medulloblastoma and constitutes a biomarker for clinical outcome in medulloblastoma. International Journal of Cancer 122: 1207-1213. *co-corresponding authors

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    Kind J, Akhtar A. (2007) Co-transcriptional recruitment of the dosage compensation complex on X-linked target genes Genes & Development 21: 2030-2040.

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    News and views:  Lall S. (2007) X chromosome exposé. Nat. Struct. Mol. Biol. 14: 794.

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    Akhtar A, Gasser, S. (2007) The nuclear envelope and transcription control. Nature Reviews Genetics 8: 507-517.

  • Download article...Savarese, F., Dávila, A., Nechanitzky, R., de la Rosa-Velazquez, I.A., Pereira, C.F., Engelke, R., Takahashi, K., Jenuwein, T., Kohwi-Shigematsu, T., Fisher, A.G., and Grosschedl, R. (2009).  Satb1 and Satb2 regulate embryonic stem cell differentiation and Nanog expression.  Genes Dev. 22, 2625-2638.

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    Dawlaty, M.M., Malureanu, L., Jeganathan, K.B., Kao, E., Sustmann, C., Tahk, S., Shuai, K., Grosschedl, R. and van Deursen, J.M. (2008).  Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha.  Cell 133, 103-115.

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    Dobreva, G., Chahrour, M., Dautzenberg, M., Chirivella, L., Kanzler, B., Farinas, I., Karsenty, G. and Grosschedl, R. (2006).  SATB2 is a multifunctional determinant of craniofacial patterning and osteoblast differentiation.  Cell 125, 971-986.

     

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    Kulathu, Y., Grothe, G. and Reth, M. (2009). Autoinhibition and adapter function of Syk. Immunol. Rev. 232(1), 286-299.

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    Herzog, S., Reth, M., and Jumaa, H. (2009). Regulation of B-cell proliferation and differentiation by pre-B cell receptor signalling. Nat Rev Immunol 9(3): 195-205.

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    von Plehwe U, Berndt U, Conz C, Chiabudini M, Fitzke E, Sickmann A, Petersen A, Pfeifer D, Rospert S (2009) The Hsp70 homolog Ssb is essential for glucose sensing via the SNF1 kinase network. Genes Dev 23: 2102-2115

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    Sharif-Naeini R, Folgering JH, Bichet D, Duprat F, Lauritzen I, Arhatte M, Jodar M, Dedman A, Chatelain FC, Schulte U, Retailleau K, Loufrani L, Patel A, Sachs F, Delmas P, Peters DJ, Honoré E. Polycystin-1 and -2 dosage regulates pressure sensing. Cell 2009; 139(3):587-96.

  • Download article...Zolles G, Wenzel D, Bildl W, Schulte U, Hofmann A, Müller CS, Thumfart JO, Vlachos A, Deller T, Pfeifer A, Fleischmann BK, Roeper J, Fakler B, Klöcker N. Association with the auxiliary subunit PEX5R/Trip8b controls responsiveness of HCN channels to cAMP and adrenergic stimulation. Neuron 2009; 62(6):814-25.

  • Download article...Schwenk J, Harmel N, Zolles G, Bildl W, Kulik A, Heimrich B, Chisaka O, Jonas P, Schulte U, Fakler B, Klöcker N. Functional proteomics identify cornichon proteins as auxiliary subunits of AMPA receptors. Science 2009; 323(5919):1313-9.

  • Download hereWeinglass AB, Kohler M, Schulte U, Liu J, Nketiah EO, Thomas A, Schmalhofer W, Williams B, Bildl W, McMasters DR, Dai K, Beers L, McCann ME, Kaczorowski GJ, Garcia ML. Extracellular loop C of NPC1L1 is important for binding to ezetimibe. Proc Natl Acad Sci USA 2008; 105(32):11140-5.

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    Yan J, Olsen JV, Park KS, Li W, Bildl W, Schulte U, Aldrich RW, Fakler B, Trimmer JS. Profiling the phospho-status of the BKCa channel alpha subunit in rat brain reveals unexpected patterns and complexity. Mol Cell Proteomics 2008; 7(11):2188-98. 

  • notavailable.pngSchulte U. Protein-protein interactions and subunit composition of ion channels. CNS Neurol Disord Drug Targets 2008; 7(2):172-86.

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    Chacinska, A., Koehler, C.M., Milenkovic, D., Lithgow, T., and Pfanner, N. (2009). Importing mitochondrial proteins: machineries and mechanisms. Cell 138, 628-644.

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    Gebert, N., Joshi, A.S., Kutik, S., Becker, T., McKenzie, M., Guan X.L., Mooga, V.P., Stroud, D.A., Kulkarni, G., Wenk, M.R., Rehling P., Meisinger, C., Ryan, M.T., Wiedemann, N., Greenberg, M.L., and Pfanner, N. (2009). Mitochondrial cardiolipin involved in outer-membrane protein biogenesis: implications for Barth syndrome. Curr. Biol. 19, 2133-2139.

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    Becker, T., Pfannschmidt, S., Guiard, B., Stojanovski, D., Milenkovic, D., Kutik, S., Pfanner, N., Meisinger, C. and Wiedemann, N. (2008) Biogenesis of the mitochondrial TOM complex: Mim1 promotes insertion and assembly of signal-anchored receptors. J. Biol. Chem. 283, 120-127.

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    Kutik, S., Stojanovski, D., Becker, L., Becker, T., Meinecke, M., Krüger, V., Prinz, C., Meisinger, C., Guiard, B., Wagner, R., Pfanner, N. and Wiedemann, N. (2008) Disssecting membrane insertion of mitochondrial beta-barrel proteins. Cell 132, 1011-1024.

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    Stojanovski, D., Milenkovic, D., Müller, J.M., Gabriel, K., Schulze-Specking, A., Baker, M.J., Ryan, M.T., Guiard, B., Pfanner, N., and Chacinska A. (2008). Mitochondrial protein import: precursor oxidation in a ternary complex with disulfide carrier and sulfhydryl oxidase. J. Cell Biol. 183, 195-202

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    Stojanovski, D., Guiard, B., Kozjak-Pavlovic, V., Pfanner, N., and Meisinger, C. (2007). Alternative function for the mitochondrial SAM complex in biogenesis of alpha-helical TOM proteins. J. Cell Biol. 179, 881-893

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    Kutik, S., Guiard, B., Meyer, H.E., Wiedemann, N., and Pfanner, N. (2007). Cooperation of translocase complexes in mitochondrial protein import. J. Cell Biol. 179, 585-591.

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    Neumann-Haefelin, E., Qi, W., Finkbeiner, E., Walz, G., Baumeister R.* and Hertweck, M.  (2008) SHC-1/p52Shc targets the insulin/IGF-1 and JNK signaling pathways to modulate life span and stress response in C. elegans. Genes Dev. 22(19):2721-35. * corresponding author.

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    Schöbel, S., Neumann, S., Hertweck, M., Dislich, B., Kremmer, E., Seed, B., Baumeister, R., Haass, C., Lichtenthaler, S.F (2008) A novel sorting nexin modulates endocytic trafficking and alpha-secretase cleavage of the amyloid precursor protein. J Biol Chem., 283, 14257-14268.

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    Tullet, J.M.A.*, Hertweck, M.* An, J.H.*, Baker, J., Oliveira, R, Baumeister, R., and Blackwell T.K. (2008) Direct inhibition of the longevity promoting factor SKN-1 by Insulin-like/DAF-2 signaling in C. elegans . Cell, 132, 1025-1038 , *first authors.

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    Dirnberger, D., Messerschmid, M., and  Baumeister R. (2008) An optimized split-ubiquitin cDNA-library screening system to identify novel interactors of the human Frizzled1 receptor. Nucl Acids Res, doi: 10.1093/nar/gkm1163

     

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    Baumeister, R., Schaffitzel, E., and Hertweck, M. (2006) Endocrine signaling in Caenorhabditis elegans controls stress response and longevity. J. Endocrinology 190, 191-202.

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    Hertweck, M., and Baumeister, R.(2004) Automated assays to study longevity in C. elegans. Mech. Aging Dev. 126, 139-145

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    Baumeister R, Hertweck M. (2004) Genes, longevity, and technology.  Science Aging Knowledge Environ.40:pe37

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    Hertweck, M., Göbel, C., and Baumeister, R. (2004) C. elegans sgk-1 is the critical component in the Akt/PKB kinase couples to control stress response and life span. Dev. Cell, 6, 577-587.

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    Köhler F, Hug E, Eschbach C, Meixlsperger S, Hobeika E, Kofer J, Wardemann H, Jumaa H. Autoreactive B cell receptors mimic autonomous pre-B cell receptor signaling and induce proliferation of early B cells. Immunity 2008 Dec 19;29(6):912-21.


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    Herzog S, Hug E, Meixlsperger S, Paik JH, DePinho RA, Reth M, Jumaa H. SLP-65 regulates immunoglobulin light chain gene recombination through the PI(3)K-PKB-Foxo pathway. Nat. Immunol. 2008 Jun:9(6):623:31


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    Meixlsperger S, Köhler F, Wossning T, Reppel M, Müschen M, Jumaa H. Conventional light chains inhibit the autonomous signaling capacity of the B cell receptor.Immunity. 2007 Mar;26(3):323-33

     

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    J. Orth, G. Schmidt, K. Aktories, Bakterielle Toxine aktivieren GTPasen durch Deamidierung. Biospektrum 05, 501 (2009).

     

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    J. H. Orth, I. Preuss, I. Fester, A. Schlosser, B. A. Wilson, K. Aktories, Pasteurella multocida toxin activation of heterotrimeric G proteins by deamidation. Proc. Natl. Acad. Sci. U. S. A 106, 7179 (2009).

     

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    I. Preuss, B. Kurig, B. Nürnberg, J. H. Orth, K. Aktories, Pasteurella multocida toxin activates Gbetagamma dimers of heterotrimeric G proteins. Cell Signal. 21, 551 (2009).

     

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    Schulte U, Thumfart JO, Klöcker N, Sailer CA, W Bildl, M Biniossek, Dehn D, Deller T,  Eble S, Abbass K, Wangler T, Knaus HG, Fakler B, The epilepsy linked lgi1 protein assembles into presynaptic kv2 channels and inhibist inactivation by kvbeta 1. Neuron 49: 697-706 (2006)

     

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    G Zolles, N Klöcker, D Wenzel, Weisser-Thomas J,  Fleischmann BK, Röper J, Fakler B, Pacemaking by HCN Channelges requires interaction with phosphoinositides. Neuron 52: 1027 - 1036 (2006)

     

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    Fakler B, Adelman JP: Control of K(Ca) channels by calcium nano/Microdomains Neuron (2008): 59(6): 873-881

     

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    Reisman, D., Glaros, S. and Thompson, E.A. (2009) The SWI/SNF complex and cancer. Oncogene 28, 1653-1668.

     

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    Wang, J., Hevi, S., Kurash, J.K., Lei, H., Gay, F., Bajko, J., Su, H., Sun, W., Chang, H., Xu, G., Gaudet, F., Li, E. and Chen, T. (2009) The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation. Nat Genet 41, 125-129.

     

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    Wang, Y., Zhang, H., Chen, Y., Sun, Y., Yang, F., Yu, W., Liang, J., Sun, L., Yang, X., Shi, L., Li, R., Li, Y., Zhang, Y., Li, Q., Yi, X. and Shang, Y. (2009) LSD1 is a subunit of the NuRD complex and
    targets the metastasis programs in breast cancer. Cell 138, 660-672.

     

 

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